If you are going to the Pagcor Casino..... generally it is quite safe in the daytime but do take precautions at night. If you take a trike DO NOT travel by Santos Ave as there is a 70-80m stretch near the Casino that is in total darkness (the street lamps are purposely switched off) where robberies frequently occur.
Always go by MacArthur Highway to the front of the casino although trikes hate going that way due to the longer distance and heavy traffic. Coming back it is safer to jump into a jeepney along the main road and drop off at MacDonalds than taking a trike.
Take note there are spotters inside the casino who will tip off their kakis outside on the big winners leaving the casino..... so if you have won a large sum please make use of the security service available from the casino (2 uniformed armed escorts and transport with driver to your hotel). The charges are reasonable and should not be a problem since you are a winner.