[lonelyfish]

Originally Posted by FromToronto

May I add, this method is not approved by the CDC nor the FDA, for Prep to reach the correct level in the blood stream it takes 21 days actually. so if one is going to raw some girl in the pussy in BKK, the bullet proof way is to start prep 21 days before. All the advanced med like Truvada (PrEP) were made in the USA, so by far the most authoritative voice in the US CDC/FDA.
However I am sure on-demand prep is effective to certain extend. The reason is also very simple, PrEP is anti-viral, it works by stopping the spread of the virus, it needs to reach certain level in the blood stream for it to work effectively. Hence the 2 in 2-1-1 is really the booster to trying to reach that blood stream level.

For receptive anal sex (bottoming), PrEP pills reach maximum protection from HIV at about 7 days of daily use.
For receptive vaginal sex and injection drug use, PrEP pills reach maximum protection at about 21 days of daily use.
No data are available for PrEP pill effectiveness for insertive anal sex (topping) or insertive vaginal sex.
We don’t know how long it takes for PrEP shots to reach maximum protection during sex.

The doctor did mention that taking it on-demand is about 10% lower effectiveness. I guess some level of protection is better than none. It is too costly to consume it daily for the max effectiveness especially when we bonk just a few girls in BKK. You can also reduce the chance by procedures like circumcision, so it adds up.